The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part II
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Decades of research went into understanding the role that Th1 autoreactive T-cells play in neuroinflammation.
Here we describe another effector population, the IL-17-producing T-helper lineage (Th17), which drives the inflammatory process.
Through the recruitment of inflammatory infiltration neutrophils and the activation of matrix metalloproteinases, IL-17, a cytokine secreted by Th17 cells, contributes to blood-brain barrier breakdown and the subsequent attraction of macrophages and monocytes into the nervous system.
The entry of cells along with the local production of inflammatory cytokines leads to myelin and axonal damage.
This activation of the inflammatory response system is induced by different pathogenic factors, such as gut bacterial endotoxins resulting in progressive neurodegeneration by Th17 cells.
Through the understanding of the role of bacterial endotoxins and other pathogenic factors in the induction of autoimmune diseases by Th17 cells, CAM practitioners will be able to design CAM therapies targeting IL-17 activity.
Targeted therapy can restore the integrity of the intestinal and blood-brain barriers using probiotics, N-acetyl-cysteine, α-lipoic acid, resveratrol and others for their patients with autoimmunities, in particular those with neuroinflammation and neurodegeneration.
American Psychological Association (APA)
Vojdani, Aristo& Lambert, Jama. 2011. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part II. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513660
Modern Language Association (MLA)
Vojdani, Aristo& Lambert, Jama. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part II. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-513660
American Medical Association (AMA)
Vojdani, Aristo& Lambert, Jama. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part II. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513660