Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy : Preliminary Study

Joint Authors

Romaniuk, Wanda
Mazurek, Urszula
Romaniuk, Dorota
Kimsa, Malgorzata W.
Kabiesz, Adam
Kimsa, Magdalena C.
Strzalka-Mrozik, Barbara

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood.

Therefore, the present study focused on the assessment of IGF1, IGF1R, and IGFBP3 mRNA levels in ERMs and PBMCs from patients with PDR.

The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs.

Quantification of IGF1, IGF1R, and IGFBP3 mRNAs was performed by real-time QRT-PCR technique.

In ERMs, IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects.

In PBMCs, there were no statistically significant differences of IGF1, IGF1R, and IGFBP3 expression between diabetic and nondiabetic patients.

In conclusion, our study indicated IGF1 and IGF1R differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders.

This trial is registered with NCT00841334.

American Psychological Association (APA)

Romaniuk, Dorota& Kimsa, Malgorzata W.& Strzalka-Mrozik, Barbara& Kimsa, Magdalena C.& Kabiesz, Adam& Romaniuk, Wanda…[et al.]. 2013. Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy : Preliminary Study. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513785

Modern Language Association (MLA)

Romaniuk, Dorota…[et al.]. Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy : Preliminary Study. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-513785

American Medical Association (AMA)

Romaniuk, Dorota& Kimsa, Malgorzata W.& Strzalka-Mrozik, Barbara& Kimsa, Magdalena C.& Kabiesz, Adam& Romaniuk, Wanda…[et al.]. Gene Expression of IGF1, IGF1R, and IGFBP3 in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy : Preliminary Study. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-513785

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-513785