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β-cyclodextrin-promazine hydrochloride interaction : conductometric and viscometric studies
Joint Authors
Kabir al-Din
Ali, Mohd Sajid
Abd al-Rubb, Malik
Khan, Farah
al-Lohedan, H. A.
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 1 (31 Jan. 2015), pp.83-87, 5 p.
Publisher
Publication Date
2015-01-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
Herein we have studied the interaction of b-cyclodextrin (b-CD) with the amphiphilic drug promazine hydrochloride (PMZ) by using conductimetry and viscometry.
From the observed results it was concluded that critical micelle concentration (cmc) of the pure drug was lower than the apparent critical micelle concentration (cmc*) of the drug in the presence of b-CD.
The cmc* increased on increasing the concentration of b-CD due to the encapsulation of the amphiphilic drug to the hydrophobic cavities of the b-CD which delayed the micelle formation.
Viscosity of the solution decreased drastically on the addition of b-CD which further increased on increasing the drug solution.
Free energies of micellization (DGmic) were calculated with the help of degrees of micelle ionization and cmc obtained from the specific conductivity_[PMZ] plots.
Micellization was found to be less spontaneous in the presence of cyclodextrin.
American Psychological Association (APA)
Ali, Mohd Sajid& Abd al-Rubb, Malik& Khan, Farah& al-Lohedan, H. A.& Kabir al-Din. 2015. β-cyclodextrin-promazine hydrochloride interaction : conductometric and viscometric studies. Journal of Saudi Chemical Society،Vol. 19, no. 1, pp.83-87.
https://search.emarefa.net/detail/BIM-518149
Modern Language Association (MLA)
Ali, Mohd Sajid…[et al.]. β-cyclodextrin-promazine hydrochloride interaction : conductometric and viscometric studies. Journal of Saudi Chemical Society Vol. 19, no. 1 (Jan. 2015), pp.83-87.
https://search.emarefa.net/detail/BIM-518149
American Medical Association (AMA)
Ali, Mohd Sajid& Abd al-Rubb, Malik& Khan, Farah& al-Lohedan, H. A.& Kabir al-Din. β-cyclodextrin-promazine hydrochloride interaction : conductometric and viscometric studies. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 1, pp.83-87.
https://search.emarefa.net/detail/BIM-518149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 86-87
Record ID
BIM-518149