Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates
Joint Authors
Rostaing, Lionel
Habibi, Hadiyah
Weclawiak, Hugo
Beaudreuil, Séverine
Allal, Asma
François, Hélène
Durrbach, Antoine
Kamar, Nasim
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 2 (30 Apr. 2015), pp.297-301, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-04-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Few studies have reported the use of double-filtration plasmapheresis (DFPP) in antibody-incompatible kidney transplantation.
To assess the efficiency and tolerability of DFPP, we prospectively studied four chronic hemodialysis patients from two centers undergoing antibody- incompatible kidney transplantation.
DFPP was used for ABO-incompatible transplantation (n = 1), for high human leukocyte antigen (HLA) immunization levels (n = 2) or for the presence of a donor-specific antibody (DSA) against a potential living donor (n = 1).
In all the patients, the DFPP program was discontinued because of the adverse effects.
Low blood pressure occurred during the first hour of the session in all the patients.
A significant loss of plasma proteins, clotting factors and immunoglobulins also occurred during this treatment.
In addition, fistula thrombosis was diagnosed in two patients.
Three patients experienced gastrointestinal symptoms.
The DFPP reduced the titers of the anti-B antibodies and reduced the levels of DSA in one patient, but had no effect on anti-HLA antibodies in the remaining two patients.
Our study highlights the non-tolerability and poor efficacy of DFPP prior to antibody-incompatible kidney transplantation that limit its extensive use in the desensitization protocols.
American Psychological Association (APA)
Habibi, Hadiyah& Weclawiak, Hugo& Rostaing, Lionel& Beaudreuil, Séverine& Allal, Asma& François, Hélène…[et al.]. 2015. Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-532563
Modern Language Association (MLA)
Habibi, Hadiyah…[et al.]. Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 2 (2015), pp.297-301.
https://search.emarefa.net/detail/BIM-532563
American Medical Association (AMA)
Habibi, Hadiyah& Weclawiak, Hugo& Rostaing, Lionel& Beaudreuil, Séverine& Allal, Asma& François, Hélène…[et al.]. Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-532563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 300-301
Record ID
BIM-532563