دراسة إنزيمية كيموحيوية لمرضى الثلاسيميا العظمى محمد عبد الرضا إسماعيل ... [و آخرون].

Abstract EN

The present study to investigate some biochemical parmeters for the thalassemia patiens.

127 Thalassemic patients in this study was selected from the Bablyon Governorate during the period of October 2012 to March 2013.

The blood samples was collection from the thalassemia center -Babylon hospital-Babylon Governorate.

The patients had mean age (15 ± 2.5) years.

The means values of hematological and biochemical were : RBC 3.53 ± 0.98 (1012 / L) Hb 8.68 ± 2.5 (g / dl) PCV 28.70 ± 8.05 for male and for female RBC 3.59 ± 0.86 (1012 / L) Hb 8.44 ± 2.46 (g / dl) PCV2 8.35 ± 7.54.

The biochemical parameters were for patients GOT 13.8 ± 8.59 U / ml GPT18.77 ± 3.9 (U / ml).

Alpactivity171 ± 29 U / l and urea concentration 5.14 ± 2.24 mmol / while the values for male and female controls were : RBC 4.65 ± 0.25 and 4.55 ± 0.14 (1012 / L) respectively, Hb 13.26 ± 0.6 and 12.69 ± 0.42 (g / dl), PCV 43.66 ± 1.44 and 42.25 ± 1.42 The biochemical parameters were for controls GOT 38.6 ± 4.49 (U / L), GPT111.7 ± 13, Alkaline phosphatase 83 ± 25 (U / L) and the urea 3.33 ± 0.60 (mmol / L).

Both values of hematological and biochemicalparameters of patients significantly deviated from the normal values (p < 0.05).

Our conclusion that The alter of the levels of some biochemical parameters in the patients in our study may be due to hepatic and myocardial and renal failures for the toxicity of iron overload, a characteristic of Thalassemia.