Simultaneous spectrophotometric determination of overlapping spectra of paracetamol and caffeine in laboratory prepared mixtures and pharmaceutical preparations using continuous wavelet and derivative transform
Joint Authors
Ashur, Ahmad
Hijazi, Maha A.
Abd al-Qawi, Muhammad
al-Zayni, Muhammad B.
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 2 (31 Mar. 2015), pp.186-192, 7 p.
Publisher
Publication Date
2015-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
In the present paper, two spectrophotometric methods were used for the simultaneous analysis of paracetamol (PCT) and caffeine (CAF) in their laboratory prepared mixtures and pharmaceutical preparations.
Simple spectrophotometric analysis of PCT and CAF is not possible due to their complete spectral overlap.
The proposed methods are based on the application of continuous wavelet transform (CWT) and derivative transform (using Savitsky–Golay filters) on the ratio spectra to predict each of CAF and PCT.
Several wavelet families were tested.
Coif1 and Sym2 were found to give best results under optimum conditions.
The transformed signals of ratio spectra were used to plot the calibration curves for both components.
The predictability of the built calibrations was validated through their application on several synthetic mixtures of both drugs.
The proposed methods were used for the prediction of CAF and PCT in pharmaceutical preparation.
The obtained results were statistically compared to a reference HPLC method.
No significant differences were found between the obtained results and those from the reference method.
Being simple, rapid, cheap and sensitive, the proposed methods are recommended for the routine daily analysis of these two drugs in their mixtures in quality control laboratories.
American Psychological Association (APA)
Ashur, Ahmad& Hijazi, Maha A.& Abd al-Qawi, Muhammad& al-Zayni, Muhammad B.. 2015. Simultaneous spectrophotometric determination of overlapping spectra of paracetamol and caffeine in laboratory prepared mixtures and pharmaceutical preparations using continuous wavelet and derivative transform. Journal of Saudi Chemical Society،Vol. 19, no. 2, pp.186-192.
https://search.emarefa.net/detail/BIM-545884
Modern Language Association (MLA)
Ashur, Ahmad…[et al.]. Simultaneous spectrophotometric determination of overlapping spectra of paracetamol and caffeine in laboratory prepared mixtures and pharmaceutical preparations using continuous wavelet and derivative transform. Journal of Saudi Chemical Society Vol. 19, no. 2 (Mar. 2015), pp.186-192.
https://search.emarefa.net/detail/BIM-545884
American Medical Association (AMA)
Ashur, Ahmad& Hijazi, Maha A.& Abd al-Qawi, Muhammad& al-Zayni, Muhammad B.. Simultaneous spectrophotometric determination of overlapping spectra of paracetamol and caffeine in laboratory prepared mixtures and pharmaceutical preparations using continuous wavelet and derivative transform. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 2, pp.186-192.
https://search.emarefa.net/detail/BIM-545884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 191-192
Record ID
BIM-545884