Immunological study on genital wart patients in Babylon Province-Iraq

Abstract EN

The aim of this study was to immune estimation of cytokine profile including serum concentration of each (IL-6, IL-10, IFN-γ andTNF-α) in genital wart patientsin Babylon Province-Iraq.

This work was applied on (40) genital wart patients who admitted to the outpatient department of Dermatology and Venereology in Merjan Medical City, Hilla-Iraq and private clinicsduring the period from November (2013) to March (2014).

A total of 40 patients (16 males and 24 females) were investigated with their age ranged from 2-48 years, in addition to 20 apparently healthy males and females be used as control with an age range approximately matched to genital wart patients.

Blood samples were collected from both patients and control to estimate the serum levels of the immune parameters Interleukine-6 (IL-6), Interlukine-10 (IL-10), Interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) by ELISA (Enzyme linked Immunosorbent Assay) method.

The cytokine profile showed that there is a significant decrease (P< 0.05) in the mean serum concentration of each (IL-6, IFN-γ and TNF-α) between study groups, indicated a decreasing in Th1 response which is responsible for cell-mediated immunity, while there was no significant difference (P >0.05) in the mean serum concentration between genital wart patients and control groups for IL-10.