Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazole derivatives : synthesis and pharmacological activity
Joint Authors
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 3 (30 Jun. 2015), pp.274-281, 8 p.
Publisher
Publication Date
2015-06-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 2a–d, 1-(pyridine-4-ylcarbonyl)-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 3a–d, 1-(5-chloro-6-fluoro-1,3-benzothiazole-2-yl)thiocarbamoyl-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 4a–d and 1-[(1,2,4-triazole-4-yl) carbothioamide]-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles 5a–d were synthesized.
The structures of the newly synthesized compounds were supported by IR, 1H NMR and mass spectral data.
These compounds were investigated for their, anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities.
Some of the synthesized compounds showed potent anti-inflammatory activity along with minimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen.
Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains.
American Psychological Association (APA)
Husayn, Sabir& Kaushik, Deepika. 2015. Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazole derivatives : synthesis and pharmacological activity. Journal of Saudi Chemical Society،Vol. 19, no. 3, pp.274-281.
https://search.emarefa.net/detail/BIM-566373
Modern Language Association (MLA)
Husayn, Sabir& Kaushik, Deepika. Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazole derivatives : synthesis and pharmacological activity. Journal of Saudi Chemical Society Vol. 19, no. 3 (2015), pp.274-281.
https://search.emarefa.net/detail/BIM-566373
American Medical Association (AMA)
Husayn, Sabir& Kaushik, Deepika. Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazole derivatives : synthesis and pharmacological activity. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 3, pp.274-281.
https://search.emarefa.net/detail/BIM-566373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 280-281
Record ID
BIM-566373