Influence of additives (inorganic-organic) on the clouding behavior of amphiphilic drug solutions : some thermodynamic studies
Joint Authors
Khan, Aftab Aslam Parwaz
Azzum, Naved
al-Din, Kabir
Asiri, Abd Allah Muhammad
Abd al-Rubb, Malik
al-Ayyubi, Abd al-Rahman O.
Khan, Anish
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 3 (30 Jun. 2015), pp.292-300, 9 p.
Publisher
Publication Date
2015-06-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Herein we provide a detailed result about the effect of various additives, viz.
inorganic salts, quaternary ammonium bromides (QABs) and amino acids on clouding behavior of amphiphilic drug amitriptyline hydrochloride (AMT).
The continuous increase in the cloud point (CP) of drug by increase in inorganic salt concentration and the magnitude of increases rely upon the position of the salts in Hofmeister series and hydrated radii.
The QABs also influence continuous increase in the CP, which is illustrated in terms of the alkyl chain length of peculiar QAB.
The effect of amino acids on CP of the drug solution is dependent upon the characteristics (acidic, basic, polar or nonpolar) of particular amino acids.
The overall behavior of additives has been analyzed and discussed on the basis of electrostatic repulsion or interaction, micellar growth, and mixed micelle formation between the ingredients.
In addition to this, thermodynamic parameters are also evaluated.
American Psychological Association (APA)
Abd al-Rubb, Malik& al-Ayyubi, Abd al-Rahman O.& Asiri, Abd Allah Muhammad& Khan, Anish& Khan, Aftab Aslam Parwaz& Azzum, Naved…[et al.]. 2015. Influence of additives (inorganic-organic) on the clouding behavior of amphiphilic drug solutions : some thermodynamic studies. Journal of Saudi Chemical Society،Vol. 19, no. 3, pp.292-300.
https://search.emarefa.net/detail/BIM-566435
Modern Language Association (MLA)
Abd al-Rubb, Malik…[et al.]. Influence of additives (inorganic-organic) on the clouding behavior of amphiphilic drug solutions : some thermodynamic studies. Journal of Saudi Chemical Society Vol. 19, no. 3 (2015), pp.292-300.
https://search.emarefa.net/detail/BIM-566435
American Medical Association (AMA)
Abd al-Rubb, Malik& al-Ayyubi, Abd al-Rahman O.& Asiri, Abd Allah Muhammad& Khan, Anish& Khan, Aftab Aslam Parwaz& Azzum, Naved…[et al.]. Influence of additives (inorganic-organic) on the clouding behavior of amphiphilic drug solutions : some thermodynamic studies. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 3, pp.292-300.
https://search.emarefa.net/detail/BIM-566435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 299-300
Record ID
BIM-566435