Prognostic significance of nuclear β-catenin expression in patients with colorectal cancer from Iran
Joint Authors
Mujarad, Ihsan Nazim al-Husayni
Kashfi, Sayyid Muhammad Husayn
Mirtalibi, Haniyah
al-Masi, Shahri
Shalishi, Wahid
Farahani, Ruya Kishani
Tarban, Piyman
Mulaei, Mahsa
Zali, Muhammad Rida
Kuppen, Peter J. K.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 7 (31 Jul. 2015), pp.1-7, 7 p.
Publisher
Publication Date
2015-07-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Beta catenin plays a key role in cancer tumorigenesis.
However, its prognostic significance in patients with colorectal cancer (CRC) remains controversial.
It has been demonstrated that 90% of all tumors have a mutation in individual components of multiple oncogenes in Wnt/β-catenin pathway.
Accumulation of nuclear β-catenin in cytoplasm leads to uncontrolled cell proliferation.
Thus, nuclear β-catenin accumulation may be a valuable biomarker associated with invasion, metastasis and poor prognosis of CRC.
Objectives : In this study the prognostic value of beta catenin expression in 165 Iranian CRC patients was evaluated.
Patients and Methods: In this cross sectional retrospective study immunohistochemistry analyses of formalin-fixed paraffin-embedded (FFPE) tumor tissues were performed to characterize the expression of nuclear β-catenin in a series of 165 Iranian patients with colorectal carcinoma.
Heat-induced antigen retrieval using the microwave method was applied for all staining procedures.
Staining was scored independently by two observers, and a high level of concordance (90%) was achieved.
Statistical analysis was done using the SPSS software for Windows, version 13.0.0 (SPSS Inc., Chicago, IL).
Two-tailed P < 0.05 was considered statistically significant.
Results : The patients consisted of 85 males and 80 females.
Eighty-eight patients had primary tumor of the rectum and sigmoid, while 77 patients had primary tumor of the colon.
The mean period of follow-up was 47.2 ± 10 months and the median period of follow-up was 38 months (range 6 - 58) for each patient.
Of 165 tumors, 32 tumors (19.39 %) showed expression of β-catenin and 133 (80.6 %) were negative for β-catenin expression.
Based on our findings the distribution of Microsatellite Instability (MSI) status differed between patients with nuclear β-catenin positive and negative tumors and this difference was significant (P = 0.001).
Patients with nuclear β-catenin positive expression profile were found to be younger than patients with negative nuclear β-catenin expression (P = 0.010).
Univariate and multivariate analysis showed that tumors with β-catenin expression had a poorer prognosis compared to tumors without β-catenin expression.
Conclusions : According to our findings, the distribution of nuclear b-catenin expression is a poor prognostic marker in patients with colon cancer.
American Psychological Association (APA)
Mujarad, Ihsan Nazim al-Husayni& Kashfi, Sayyid Muhammad Husayn& Mirtalibi, Haniyah& al-Masi, Shahri& Shalishi, Wahid& Farahani, Ruya Kishani…[et al.]. 2015. Prognostic significance of nuclear β-catenin expression in patients with colorectal cancer from Iran. Iranian Red Crescent Medical Journal،Vol. 17, no. 7, pp.1-7.
https://search.emarefa.net/detail/BIM-593583
Modern Language Association (MLA)
Mujarad, Ihsan Nazim al-Husayni…[et al.]. Prognostic significance of nuclear β-catenin expression in patients with colorectal cancer from Iran. Iranian Red Crescent Medical Journal Vol. 17, no. 7 (Jul. 2015), pp.1-7.
https://search.emarefa.net/detail/BIM-593583
American Medical Association (AMA)
Mujarad, Ihsan Nazim al-Husayni& Kashfi, Sayyid Muhammad Husayn& Mirtalibi, Haniyah& al-Masi, Shahri& Shalishi, Wahid& Farahani, Ruya Kishani…[et al.]. Prognostic significance of nuclear β-catenin expression in patients with colorectal cancer from Iran. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 7, pp.1-7.
https://search.emarefa.net/detail/BIM-593583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-593583