Synthesis of some substituted 1, 3, 4-oxadiazoles, thiadiazoles and 1, 2, 4-triazoles
Author
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 22, Issue 2 (30 Jun. 2009), pp.29-37, 9 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2009-06-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported.
Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1).
The hydrazide was converted to 1-acyl thiosemicarbazide (2) byits reaction with ammonium thiocyanate, which was treated with sodium hydroxide solution and with concentrated sulfuric acid to give 5-substituted-1,2,4-triazoles-3-thiol (3) and 2-substituted-5-amino-1,3,4- thiadiazole (4) respectively.
The acid hydrazide (1) was treated with benzaldehyde or substituted benzaldehyde to give hydrazones (7-12), the hydrazones were then cyclized with lead dioxide to 2-subtituted-5-phenyl 1,3,4-oxadiazole (14).
The reaction of the hydrazide (1) with formic acid gave 1-formyl-2-acyl hydrazine (6) and the cyclization of (6) by phosphorus pentaoxide gave monosubstituted-1,3,4-oxadiazoles (13).
Acid hydrazide (1) was treated with phenyl isothiocyanate to give substituted thiosemicarbazide (5).
The structure of the synthesized compounds were confirmed by physical and spectral means.
American Psychological Association (APA)
Muhammad, Shirin R.. 2009. Synthesis of some substituted 1, 3, 4-oxadiazoles, thiadiazoles and 1, 2, 4-triazoles. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 22, no. 2, pp.29-37.
https://search.emarefa.net/detail/BIM-622025
Modern Language Association (MLA)
Muhammad, Shirin R.. Synthesis of some substituted 1, 3, 4-oxadiazoles, thiadiazoles and 1, 2, 4-triazoles. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 22, no. 2 (Jun. 2009), pp.29-37.
https://search.emarefa.net/detail/BIM-622025
American Medical Association (AMA)
Muhammad, Shirin R.. Synthesis of some substituted 1, 3, 4-oxadiazoles, thiadiazoles and 1, 2, 4-triazoles. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2009. Vol. 22, no. 2, pp.29-37.
https://search.emarefa.net/detail/BIM-622025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 37
Record ID
BIM-622025