Comparing the effect of adding dexmedetomidine versus dexamethasone on prolonging the duration of intrathecal bupivacaine in lower abdominal operations
Joint Authors
Jirjis, Karim
al-Zayyat, Nashwa Sami
Naji, Hibah Ismail Ahmad
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 7, Issue 3 (31 Dec. 2014), pp.388-392, 5 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Objective The aim of this study was to evaluate the effi cacy of adding dexmedetomidine compared with dexamethasone to bupivacaine to prolong the duration of spinal anesthesia and analgesia in lower abdominal operations.
Patients and methods This randomized double-blind study included 60 ASA I or II patients, aged between 25 and 55 years old, scheduled for lower abdominal operations.
They were administered 0.5% intrathecal bupivacaine injection and randomly divided into one of three groups: control group (GC), in which patients were administered additional 1 ml of saline; GDX group, in which patients were administered 4 mg dexamethasone; and GDM group, in which patients were administered 10 μg dexmedetomidine.
The patients were monitored for heart rate, mean arterial pressure, oxygen saturation, onset and duration of sensory and motor block, intraoperative and postoperative sedation and pain, and adverse events.
Results Compared with GC, GDM had signifi cantly faster onset of sensory block (P = 0.006), longer duration of sensory block (P < 0.001), longer duration of motor block (P = 0.013), longer duration of postoperative analgesia (P < 0.001), and signifi cantly higher sedation score (P < 0.001).
Compared with GDX, GDM had signifi cantly longer duration of sensory block (P = 0.025) and longer duration of postoperative analgesia (P < 0.001).
Compared with GC, GDX had signifi cantly longer duration of sensory block (P < 0.001) and longer duration of postoperative analgesia (P < 0.001).
The three groups were comparable in terms of the onset of motor block (P = 0.637) and frequency of adverse events.
Conclusion Intrathecal dexmedetomidine and dexamethasone are safe and effective adjuncts to intrathecal bupivacaine anesthesia in lower abdominal surgery.
Dexmedetomidine showed to provide more rapid onset and longer duration of sensory block, longer duration of motor block, and longer postoperative analgesia.
American Psychological Association (APA)
al-Zayyat, Nashwa Sami& Naji, Hibah Ismail Ahmad& Jirjis, Karim. 2014. Comparing the effect of adding dexmedetomidine versus dexamethasone on prolonging the duration of intrathecal bupivacaine in lower abdominal operations. Ain Shams Journal of Anesthesiology،Vol. 7, no. 3, pp.388-392.
https://search.emarefa.net/detail/BIM-652306
Modern Language Association (MLA)
al-Zayyat, Nashwa Sami…[et al.]. Comparing the effect of adding dexmedetomidine versus dexamethasone on prolonging the duration of intrathecal bupivacaine in lower abdominal operations. Ain Shams Journal of Anesthesiology Vol. 7, no. 3 (Sep. / Dec. 2014), pp.388-392.
https://search.emarefa.net/detail/BIM-652306
American Medical Association (AMA)
al-Zayyat, Nashwa Sami& Naji, Hibah Ismail Ahmad& Jirjis, Karim. Comparing the effect of adding dexmedetomidine versus dexamethasone on prolonging the duration of intrathecal bupivacaine in lower abdominal operations. Ain Shams Journal of Anesthesiology. 2014. Vol. 7, no. 3, pp.388-392.
https://search.emarefa.net/detail/BIM-652306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 392
Record ID
BIM-652306