دراسة دور sICAM-1 و بعض الواصمات المناعية في الربو القصبي لدى الأطفال

Abstract EN

Adhesion molecules (ICAMs) and one of them called Intracellular Adhesion Molecules (ICAM-1) have an important role in asthma, by regulating cell infiltration to lungs and mediating in asthma inflammation phase.

The presence of ICAM-1 on the surface of airways endothelial cells results in eosinophil adhesion first, then lymphocyte and finally monocyte, as a reaction of airways triggers.

Eosinophil activation results in degranulation and releasing ECP (Eosinophil Cationic Protein), that has an important role in airways inflammation, it is cytotoxic, neurotoxic, and has a role in chronic remodeling lung tissue and it stimulates bronchial smooth muscle death by necrosis.

So the aim of this study is to detect the differences of serum sICAM-1 and ECP levels between children with asthma and healthy controls.

The study group involved 88 samples (28 patients with mild intermittent asthma, 16 mild persistent asthma, 12 moderate persistent asthma, 12 severe persistent asthma, and 20 controls).

ICAM-1 and ECP were tested by the enzyme-linked immune sorbent assay (ELISA).

Serum ECP levels were higher in patients than controls, but sICAM-1 levels were not higher.

Neither significant differences between patients and controls, nor a correlation between sICAM-1 and ECP, were found.