تعيين قيم Caspase-3 و Caspase-7 لدى مرضى سرطان ثدي سوريين معالجين
Other Title(s)
Determination the values of "Caspase-3 and Caspase-7" in treated Syrian breast cancer patients
Joint Authors
Source
Issue
Vol. 7, Issue 3-4 (31 Jul. 2014), pp.59-68, 10 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2014-07-31
Country of Publication
Syria
No. of Pages
10
Main Subjects
Topics
Abstract EN
Caspase-3 is a member of Cysteine protease family, which plays a crucial role in apoptosis pathway by diverse death-inducing signals, including the chemotherapeutic agents.
The aim of this study is to evaluate the efficacy of clinical response in assessing the Chemo-sensitivity/ resistance in correlation with caspases-3 fold increase, in advanced breast cancer, and measure of Caspase-7 serum levels to assure the activation of caspase cascade.
The study included 60 patients, divided into two groups: 39 advanced breast cancer patients and 21 were control subjects.
We measured the serum levels of Caspase-3 and Caspase-7 prior to chemotherapy, after 24 hours from the 1st cycle and after one week from the 3rd Cycle.
Caspase-3 and Caspase-7 were measured by double sandwich ELISA Kits.
The study showed a strong correlation (r=0.846) between caspase-3 fold increase and the final clinical response.
There was 0 - 0.9 and ≥ 1 fold increase in Caspase-3 serum levels, after 24 hours from the 1st cycle, in clinical progressive or stable disease and clinical partial or complete response, respectively.
The study suggests that Caspase-3 is useful as a good marker to predict chemosensitivity/resistance.
American Psychological Association (APA)
حمود، هيمى والصالح، جمانة. 2014. تعيين قيم Caspase-3 و Caspase-7 لدى مرضى سرطان ثدي سوريين معالجين. مجلة التشخيص المخبري،مج. 7، ع. 3-4، ص ص. 59-68.
https://search.emarefa.net/detail/BIM-668009
Modern Language Association (MLA)
حمود، هيمى والصالح، جمانة. تعيين قيم Caspase-3 و Caspase-7 لدى مرضى سرطان ثدي سوريين معالجين. مجلة التشخيص المخبري مج. 7، ع. 3-4 (تموز 2014)، ص ص. 59-68.
https://search.emarefa.net/detail/BIM-668009
American Medical Association (AMA)
حمود، هيمى والصالح، جمانة. تعيين قيم Caspase-3 و Caspase-7 لدى مرضى سرطان ثدي سوريين معالجين. مجلة التشخيص المخبري. 2014. مج. 7، ع. 3-4، ص ص. 59-68.
https://search.emarefa.net/detail/BIM-668009
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 67-68
Record ID
BIM-668009