دراسة قدرة الكبد على تصنيع البروتينات و تأثيرها على سلامة خلايا الكبد لدى المسنين من الرجال العراقيين

Abstract EN

Liver ability to manufacture proteins is one of the main functions of the liver.

The aim of this study is to test the ability of liver to manufacture proteins through measuring levels of total protein and its parts, then studying the impact of this ability on the function of liver cells of elderly Iraqi men by determining the activity of liver cells enzymes; Glutamate Oxalic transaminase (GOT) and Glutamate Pyruvic Transaminase (GPT).

Blood samples were collected from 72 volunteer, divided into two groups.

The first included 36 men (50-65 years old) who have not been registered with any organic injury in liver, kidneys pancreas, heart, and urinary system.

Thirty sex healthy samples (20-25 years old).

had been included in the second group as control.

Levels of total protein± SD of two categories were somewhat similar (7.00±1.05 and 7.30 ± 1.23 g\dl) respectively, while values of albumin possessed elevation in aged men than control (5.766 ± 1.3 vs.4.36 ± 7.9 g\dl), in addition, it seems that globulin had a lower level in elderly than in youngest men (1.24 g\dl vs.

2.93 g\dl).

That imbalance in blood protein parts leads to disrupt liver enzymes activity, where GOT activity elevated to 21.73 U/L when compared to its activity in control subjects 11.87 U/L, and the activity of GPT was 26.66 U\L if compared with control 22.07U\L (r=0.37,p<0.03).

Our results indicate a commotion in protein parts concentrations in aged men, which might lead to a damage of liver cells.