العلاقة بين وجود التعدد الشكلي CYP1A1*2A و الجنس و العمر و النمط المناعي لدى أطفال سوريين مصابين بالابيضاض اللمفاوي الحاد

Abstract EN

Although the clinical, pathological, and immunophenotypic features of ALL are well documented.

The causes of childhood leukemia continue to be incompletely explained, but have been linked to environmental exposure and multiple low penetrance genetic factors.

CYP1A1, a member of the cytochrome P450 (CYP) enzymes, plays a very important role in the metabolizing of carcinogens.

This study aimed to detect the frequency of CYP1A1*2A polymorphism in Syrian children with acute lymphoblastic leukemia (ALL), and find out the role of this polymorphism, if any, as a risk factor for developing ALL in children.

70 children with acute lymphoblastic leukemia with 45 healthy controls were studied.

Genomic DNA was extracted and restriction fragment length polymorphism (RFLP) based PCR was applied, followed by digestion with MspI.

Among 70 ALL patients, 8.6% were heterozygous for the CYP1A1*2A genotype, compared with 4.4% of controls.

The difference between the groups were found not to be statistically significant (OR 2.016; 95% CI 0.39-10.46).

As conclusion, the results did not show any association between CYP1A1*2A genotypes and risk of ALL in Syrian children.