Association study of dopamine β-hydroxylase gene with methamphetamine psychosis
Joint Authors
Ozaki, Norio
Okahisa, Yuko
Ujike, Hiroshi
Takaki, Manabu
Mizuki, Yutaka
Sakamoto, Shinji
Mujun, Won
Kondo, Naoki
Naruse, Nobuya
Iyo, Masaomi
Sora, Ichiro
Uchitomi, Yosuke
Aoyama Uehara, Kumi
Iwata, Nakao
Source
Journal of Drug and Alcohol Research
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
English Abstract
Dopamine is a key molecule in the pathophysiology of methamphetamine (METH) psychosis.
We examined the association between METH psychosis and the dopamine β-hydroxylase (DBH) gene, which modulates dopaminergic cascades.
Six polymorphisms, rs1989787, rs1611115, rs1108580, rs5320, rs1611125, and rs6271, of the DBH gene were genotyped.
These polymorphisms were not associated with METH-seeking behaviors of patients with METH psychosis (N = 216) or healthy controls (N = 328), but rs1611125 affected one of the clinical phenotypes ofMETH psychosis.
Individuals with the G/G homozygote of rs1611125 had a significant risk for spontaneous relapse of METH psychosis (P = .02, odds ratio = 2.2).
In haplotype analyses, rs1108580-rs5320-rs1611125 was revealed to be associated with METH psychosis (P = .01).
Having G-Ala-G was a significant risk factor, while A-Thr-A was a protective factor for METH psychosis (odds ratio were 9.9 and 0.16, resp.).
Our present findings indicated that the DBH gene may play an important role in METH psychosis.
Data Type
Conference Papers
Record ID
BIM-685842
American Psychological Association (APA)
Okahisa, Yuko& Ujike, Hiroshi& Takaki, Manabu& Mizuki, Yutaka& Mujun, Won& Sakamoto, Shinji…[et al.]. 2014-12-31. Association study of dopamine β-hydroxylase gene with methamphetamine psychosis. International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico). . Vol. 3 (2014), pp.1-6.Cairo Egypt : Ashdin Publishing Corporation.
https://search.emarefa.net/detail/BIM-685842
Modern Language Association (MLA)
Mujun, Won…[et al.]. Association study of dopamine β-hydroxylase gene with methamphetamine psychosis. . Cairo Egypt : Ashdin Publishing Corporation. 2014-12-31.
https://search.emarefa.net/detail/BIM-685842
American Medical Association (AMA)
Okahisa, Yuko& Ujike, Hiroshi& Takaki, Manabu& Mizuki, Yutaka& Mujun, Won& Sakamoto, Shinji…[et al.]. Association study of dopamine β-hydroxylase gene with methamphetamine psychosis. . International Meeting of Drug Abuse Research Society : Advances in the Neurobiological Basis of Inhalant Abuse (4th : 2013 : Mexico City, Mexico).
https://search.emarefa.net/detail/BIM-685842
