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PPAR-δ agonist rescue of brain insulin IGF signaling impairments following developmental exposure to alcohol
Joint Authors
Le, Tran
Monte, Suzanne M. de la
Ewenczyk, Alexandra
Conoway, Ashley
Ziplow, Jason
Nguyen, Quynh Giao
Chen, William Cy
Zabala, Valerie
Source
Journal of Drug and Alcohol Research
Issue
Vol. 2, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Neurodevelopmental abnormalities in fetal alcohol spectrum disorder (FASD) are associated with impaired insulin and IGF signaling, which is needed for neuronal growth, survival, and plasticity.
We characterized effects of the L-165,041 PPAR-δ agonist insulin sensitizer on cerebellar structure and function in relation to insulin/IGF and neurotrophin signaling in an FASD model.
Methods.
On postnatal days (P) 2, 4, 6, and 8, rat pups were administered (i.p.) 2 g/kg of ethanol or saline; and on P5, P7, P9, and P11, they were treated with saline or L-165,041.
Rotarod tests assessed motor function.
Cerebella were studied biochemically.
Results.
Ethanol-impaired motor function and signaling through the insulin receptor and Akt were abrogated by PPAR-δ agonist treatments, whereas neurotrophin expression was unaffected.
Conclusions: PPAR-δ agonists may help normalize cerebellar function in FASD by supporting insulin signaling through cell survival pathways, but additional approaches are needed to restore neurotrophin expression for neuronal plasticity
American Psychological Association (APA)
Ewenczyk, Alexandra& Conoway, Ashley& Ziplow, Jason& Le, Tran& Nguyen, Quynh Giao& Chen, William Cy…[et al.]. 2013. PPAR-δ agonist rescue of brain insulin IGF signaling impairments following developmental exposure to alcohol. Journal of Drug and Alcohol Research،Vol. 2, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-687268
Modern Language Association (MLA)
Ewenczyk, Alexandra…[et al.]. PPAR-δ agonist rescue of brain insulin IGF signaling impairments following developmental exposure to alcohol. Journal of Drug and Alcohol Research Vol. 2 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-687268
American Medical Association (AMA)
Ewenczyk, Alexandra& Conoway, Ashley& Ziplow, Jason& Le, Tran& Nguyen, Quynh Giao& Chen, William Cy…[et al.]. PPAR-δ agonist rescue of brain insulin IGF signaling impairments following developmental exposure to alcohol. Journal of Drug and Alcohol Research. 2013. Vol. 2, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-687268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-11
Record ID
BIM-687268