An immunohistochemical expressions of BAD, MDM2, and P21 in oral squamous cell carcinoma
Joint Authors
Sarkis, Seta A.
Khalil, Afrah A.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 2 (30 Jun. 2016), pp.34-39, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Oral squamous cell carcinoma (OSCC) is a common malignancy characterized by poor prognosis and low survival rate.
The purpose of this study was to evaluate the Immunohistochemical expressions of BAD, MDM2, and P21as apoptotic markers in oral squamous cell carcinoma.
Materials and methods: This study was performed on forty formalin-fixed paraffin-embedded blocks which histopathologically diagnosed as Oral Squamous Cell Carcinoma.
All cases were collected from the Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi Teaching Hospital, Iraq.
Results : The immunohistochemical staining of BAD showed positive expression in 39 (97.5 %), MDM2 showed positive expression in 39(97.5 %) and P21showed positive expression in 34(85 %) of the collective cases.
Conclusion : A statistically significant correlation was found regarding MDM2 with the tumor site, P21 with tumor grade.
American Psychological Association (APA)
Khalil, Afrah A.& Sarkis, Seta A.. 2016. An immunohistochemical expressions of BAD, MDM2, and P21 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 2, pp.34-39.
https://search.emarefa.net/detail/BIM-691804
Modern Language Association (MLA)
Khalil, Afrah A.& Sarkis, Seta A.. An immunohistochemical expressions of BAD, MDM2, and P21 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 2 (Jun. 2016), pp.34-39.
https://search.emarefa.net/detail/BIM-691804
American Medical Association (AMA)
Khalil, Afrah A.& Sarkis, Seta A.. An immunohistochemical expressions of BAD, MDM2, and P21 in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 2, pp.34-39.
https://search.emarefa.net/detail/BIM-691804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 38-39
Record ID
BIM-691804