Effect of topical morphine on cutaneous leishmaniasis in an animal model : a preliminary report
Joint Authors
Karimi, Ali Asghar
Ghaffarpasand, Fariborz
Akbarzadeh, Afsoon
Heiran, Hamid Rida
Ghobadifar, Muhammad Amin
Akbarzadeh, Armin
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 5 (31 May. 2016), pp.1-5, 5 p.
Publisher
Publication Date
2016-05-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Pentavalent antimonials remain the choice of treatment for leishmaniasis, despite their toxicity, high cost, and difficult administration.
As an alternative, morphine may induce the healing process of cutaneous leishmaniasis by its immunoregulatory characteristics.
Objectives: To study the effect of morphine on the wound-healing process of cutaneous leishmaniasis (CL) in a mouse model.
Materials and Methods: This was an experimental study in which 40 BALB/c mice (female, 6 - 8 weeks) were divided into four groups (eachn= 10)whoreceived either placebo alone (group 1), morphine ointment after parasite inoculation (group 2), morphine ointment after wound occurrence (group 3), or placebo after wound occurrence (group 4).
Wound size was measured weekly for eight weeks.
Results: On the first day of treatment, the lesions measured 1.5mmin diameter.
After eight weeks of treatment, the wound size was significantly smaller in the mice who received morphine ointment (4.813.22 mm) compared to those who received placebo after parasite inoculation (8.955.71 mm; P = 0.0001) or placebo after wound occurrence (P = 0.028).
Conclusions: The above data suggest that topical application of morphine accelerates the healing process of CL wounds.
We are cautiously optimistic that the results of this study can be used clinically for potentiating CL wound-healing.
American Psychological Association (APA)
Ghaffarpasand, Fariborz& Akbarzadeh, Afsoon& Heiran, Hamid Rida& Karimi, Ali Asghar& Akbarzadeh, Armin& Ghobadifar, Muhammad Amin. 2016. Effect of topical morphine on cutaneous leishmaniasis in an animal model : a preliminary report. Iranian Red Crescent Medical Journal،Vol. 18, no. 5, pp.1-5.
https://search.emarefa.net/detail/BIM-694701
Modern Language Association (MLA)
Ghaffarpasand, Fariborz…[et al.]. Effect of topical morphine on cutaneous leishmaniasis in an animal model : a preliminary report. Iranian Red Crescent Medical Journal Vol. 18, no. 5 (May. 2016), pp.1-5.
https://search.emarefa.net/detail/BIM-694701
American Medical Association (AMA)
Ghaffarpasand, Fariborz& Akbarzadeh, Afsoon& Heiran, Hamid Rida& Karimi, Ali Asghar& Akbarzadeh, Armin& Ghobadifar, Muhammad Amin. Effect of topical morphine on cutaneous leishmaniasis in an animal model : a preliminary report. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 5, pp.1-5.
https://search.emarefa.net/detail/BIM-694701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-694701