دراسة واصمي التقلب العظمي CTX-1 و OC لتقييم حالة تخلخل العظم لدى نساء بعد الإياس

Abstract EN

Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility.

It is a chronic progressive disease of multifactorial etiology, and one of the most common metabolic bone diseases frequently recognized in postmenopausal women.

This is due to accelerated bone remodeling as a consequence of estrogen withdrawal.

Currently bone mineral density is the WHO standard for diagnosis of osteoporosis.

This study aimed to determine the relationship between two biochemical bone markers, Carboxy-terminal telopeptide of type 1 collagen (CTX-1) and osteocalcin (OC), in comparison with bone mineral density (BMD), to investigate their clinical role in the assessment of bone status in women with postmenopausal osteoporosis.

Serum CTX-1 and OC were measured, by enzyme linked immunosorbant assay (ELISA), in 77 postmenopausal women, which divided depending on BMD, into three groups: healthy, osteoporotic and osteopenic women.

The spine and femur bone mineral density (BMD) were determined by dualenergy X-ray absorptiometry (DXA).

The relationships between the two biochemical markers of bone turnover CTX-1 and OC to each other, age, body mass index (BMI) and BMD were analyzed.

No correlation was found between serum levels of each OC, CTX-1 and age, BMI, and spine or femur bone mineral density.

But there was a significant correlation (p= 0.0001 and r=0.912) between the two markers (CTX-1 and OC).

Conclusion: Serum levels of CTX-1 and OC have limited clinical value in the evaluation of bone status in postmenopausal women.