A study of the relationship between serum 25 hydroxyvitamin d levels and severity of bronchial asthma in children

Abstract EN

Background: vitamin D has an important role in innate immunity, including the prevention of respiratory tract infections.

Vitamin D exerts many of its effects through contact with vitamin D receptors, which have been found in a variety of cells, including lung cells and many cells of the immune system Objective: TO evaluate of the role of vitamin D in bronchial asthma.

Subjects and Methods: The study was conducted on 120 children (60 asthmatics and 60 healthy controls) during the period of from March 2012 to September 2012.

Patients were attending the Pediatric Chest Clinic, Children’s Hospital, Faculty of Medicine, Ain Shams University.

Serum 25 hydroxyvitamin D level was done by ELISA in both patients and controls.

Results: The mean value of serum 25- OH vitamin D of patients (26.98±6.59 ng/ ml) was significantly lower than that of controls (42.67±7.26 ng/ ml) (p value <0.01).

Vitamin D level decreases with increased asthma severity.

Conclusion: The mean serum 25- OH vitamin D of patients group was significantly lower than control group.

Lower levels of serum vitamin D are associated with increased asthma severity