الأهمية التشخيصية للواصمات المناعية الذاتية للخلايا بيتا البنكرياسية لتحديد الداء السكري المناعي الذاتي الخافِي عند البالغين في محافظة اللاذقية-سورية

Abstract EN

This study aims to evaluate the frequency of islet β-cell autoimmune markers, such as islet cell autoantibody (ICA(, glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase autoantibody (IA-2), and insulin autoantibody (IAA) in a group of type 2 diabetics with c-peptide ≥1.2 ng/ml to define latent autoimmune diabetes of adults (LADA) in the city of Latakia - Syria.

Based on the positivity of at least one of the islet β-cell autoantibodies (ICA, GADA, IA-2, or IAA) LADA was identified.

A group of type 2 diabetic pateints (n=70) with c-peptide ≥1.2 ng/ml were studied and patients with positive IAA who were treated with insulin were excluded.

The majority of patients (53 out of 70 patients) diagnosed as having autoimmune diabetes based on the positivity of ICA+ (sensitivity 94%; n=50), IAA+ (sensitivity 37%; n=20), GADA+ (sensitivity 22%; n =12) and/or IA2+ (sensitivity 4%; n=2).

Both GADA+ and IA2+ patients were ICA+ positive as well.

In IAA+ positive patients (n= 20), 3 subjects were diagnosed as having LADA based on only IAA positivity.

Therefore, the frequency of positivity of both ICA+ and IAA+ covered all the studied group of LADA.

Conclusion: Diagnostically, both ICA and IAA almost have 100% diagnostic value in identifying LADA in type 2 diabetics with c-peptide ≥1.2 ng/ml in Latakia