الاختلاطات القريبة و البعيدة في ازدراع الكلية من الجثث عند الأطفال و علاقتها باستخدام خطة المعالجة ب Alemtuzumab و تاكروليموس و ميكوفينولات موفيتايل و دون ستيرونيدات قشرية

Abstract EN

Background & Objective: The early and late complications of using Campath-H1 without steroid with immunosuppressive therapy (Tacrolimus and MMF) was controversial in adult population .

But, the result of study in pediatric population was encouraging.

Materials & Methods: The study was prospective and done at Stony Brook University, Medical center.

New York.

USA; in the period from March2006 ،20 ، to March2010 ،18 ، "four year period".

We investigated 10 pediatric decease transplanted kidney from 16 transplantation at this time ( 62.5%), the time of follow up was (3- 42 ) months.

The boys were 6 and the girls were 4.

Results: The surgical complications occurred in 10% (in one patient).

The incision dehiscence and infection found in a one patient also (10%).The delayed graft function happened in a one patient (10%) due to congestive heart failure after.

Renal transplantation.

The acute renal failure didn't occur in any patient.

The viral infection (BK/CMV) didn't find in any patient.

The post-transplantation diabetes didn't develop in our patients.

The post-transplantation lymphoproliferative disorder didn't develop in any patient.

The mean of creatinine at 1,2,3,4 ،year of fallow up was1.0 ، ± 0.97 ،0.3 ± ،0.04 0.83 ± ،0.21 0.82 ± 0.18 The survival rate for graft and patient was 100% and 100%, for each, respectively.

Conclusion: Use of the following protocol in deceased donor transplantation in children: Campath-H1 (Alemtuzumab) as an induction therapy with 3 dose methylprednisolone daily.

Without glucocorticoids after day 3 and Tacrolimus with Mycofenolate mofetil was very effective and save .Surgical complications and prolonged graft function was acceptable with wall world result.

The acute rejection, viral infection ،and chronic allograft nephropathy was null for 4 years follow up after transplantation