تقييم الواصمات الخثارية عند مرضى التهاب الأنسجة حول السنية المزمن

Abstract EN

Background& Objective: Chronic Periodontitis is accompanied with subacute systemic inflammatory responses and a procoagulant state which manifests in changes of some serological vascular thrombotic markers levels.

This study aimed to evaluate several vascular thrombotic markers levels in patients with chronic periodontitis.

Materials & Methods: Study population consisted of 60 individuals ,36 males, 24 females, aged between 30- 48 years, (mean 36.33 years) , were divided into 2 groups; the first, (n=20),was the control healthy individuals, and the second, (n=40),was patients with chronic periodontitis.

Registration included, systolic blood pressure(sBP), body mass index and the periodontal disease indices; dental plaque(PI), gingival inflammation(GI), bleeding on probing(BOP), pocket probing depth(PPD),clinical attachment loss(CAL).

Blood tests included platelets count(Plt), fibrinogen(Fib), prothrombin time(PT), activated partial thromboplastin (aPTT), and Von Willebrand factor antigen (vWF:Ag).

Statistics, included independent Ttest and Pearson correlation, were performed at (P<0.05) by means of SPSS 19th ed.

Results: There were significant differences between the two groups in (sBP) (P=0.022), (Plt) (P=0.004), (Fib) (P=0.001), (vWF:Ag) (P=0.011), and in all of the periodontal indices (P<0.05).

Furthermore, there was a significant moderate positive correlation (r= 0.4, P<0.05) between all of the periodontal indices thrombotic markers, and was more evident in (Plt) with (GI), (Fib) with (PI), (GI), (BOP), (PPD), and (vWF:Ag) with (PI).

Conclusion: Periodontitis was associated with higher values of systolic blood pressure, platelets count, fibrinogen level, Von Willebrand factor activity, and periodontal indices positively correlated with the thrombotic markers.

These findings would point out to the role of the periodontal disease as a risk indicator in precipitating a procoagulant state.