تأثير مستخلص بذور البلنكو Lallemantia royleana في مستوى إنزيمات وظائف الكبد و في بعض معالم نشاط الفئران المعاملة بعقار الريفادين
Other Title(s)
Effect of Lallemantia royleana seeds extract in liver functions enzymes levels and in some mice activity features treated with Rifadin drug
Joint Authors
البرام، محمد فاضل عبد الحسين
الأسدي، زينب ثامر شويت
Source
مجلة ابن الهيثم للعلوم الصرفة و التطبيقية
Issue
Vol. 29, Issue 2 (31 Aug. 2016), pp.358-366, 9 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2016-08-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
This study was aimed to investigate the role of crud alcoholic extract of Lallemantia royleana seeds in reducing the hepatotoxicity and side effect of rifadin drug in liver.
The animals (40 mice) were divided into four groups, the first group was treated with normal saline (0.9%) for 28 days as a control and the second group was treated with rifadin (1.5 mg/kg/day) for 28 days and third group was treated with acoholic extract of Lallemantia royleana seeds (1% w/v) for 28 days, while the forth group was treated with alcoholic extract of seeds alone for 5 days and with alcoholic extract and rifadin for 28 days, so the total period of this group is 33 days.
The blood samples ware collected to measure the liver function enzymes represented by Alkalin phosphatse (ALP), Alanine transaminase (ALT), Aspartate Transaminase (AST), and the animals in experimental groups were observed to investigate the animals activity changes in groups after treated with drug and extract.
Significant increases (P<0.05) were found in the levels of liver function enzymes (ALT,AST,ALP) in drug treated group ( 131.575±3.45، 662.04±8.26، 197.00±6.58) comparing with control group (33.440±2.27، 264.10±2.52، 74.98±1.79) and significant decrease (P<0.05) in ALT,AST levels in extract treated group (47.480±1.93 ،254.18±4.34) and the extract-drug treated group (85.033±2.33، 444.86±4.56) comparing to drug treated group.
The animal activity changes that noted in drug group represented by lethargy, introversion, the tendency to sleep, hyperventilation, in addition to change the faeces color to black and urine color to ruddy, in other hand these behavioral changes were decreased in animals groups treated with extract and extract-drug togather comparing to drug group.
American Psychological Association (APA)
البرام، محمد فاضل عبد الحسين والأسدي، زينب ثامر شويت. 2016. تأثير مستخلص بذور البلنكو Lallemantia royleana في مستوى إنزيمات وظائف الكبد و في بعض معالم نشاط الفئران المعاملة بعقار الريفادين. مجلة ابن الهيثم للعلوم الصرفة و التطبيقية،مج. 29، ع. 2، ص ص. 358-366.
https://search.emarefa.net/detail/BIM-746008
Modern Language Association (MLA)
البرام، محمد فاضل عبد الحسين والأسدي، زينب ثامر شويت. تأثير مستخلص بذور البلنكو Lallemantia royleana في مستوى إنزيمات وظائف الكبد و في بعض معالم نشاط الفئران المعاملة بعقار الريفادين. مجلة ابن الهيثم للعلوم الصرفة و التطبيقية مج. 29، ع. 2 (2016)، ص ص. 358-366.
https://search.emarefa.net/detail/BIM-746008
American Medical Association (AMA)
البرام، محمد فاضل عبد الحسين والأسدي، زينب ثامر شويت. تأثير مستخلص بذور البلنكو Lallemantia royleana في مستوى إنزيمات وظائف الكبد و في بعض معالم نشاط الفئران المعاملة بعقار الريفادين. مجلة ابن الهيثم للعلوم الصرفة و التطبيقية. 2016. مج. 29، ع. 2، ص ص. 358-366.
https://search.emarefa.net/detail/BIM-746008
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن ملحق : ص. 365
Record ID
BIM-746008