التقدير الطيفي للباراسيتامول بوساطة الازوتة و الاقتران مع حامض الانثرالنك

Abstract EN

This paper concerned with development of a spectrophotometric method for the determination of paracetamol, based on the diazotisation and coupling reaction with anthranilic acid in basic medium, to form an intense yellow coloured, water-soluble and stable azo-dye which shows a maximum absorption at 421nm.

Beer’s law is obeyed over the concentration range of 1.0-10 μg/ml; with molar absorptivity of 2.1772×104 L.mol-1.cm-1 and Sandell’s sensitivity index 6.9446 μg.cm-2.

The method has been applied successfully for the determination of paracetamol in pharmaceutical formulation.