تقييم تكرار الطفرات الوراثية لجينات BRCA 1 و RBCA2 في النساء المصابات بسرطان الثدي في محافظة النجف الأشرف

Joint Authors

الطريحي، قسور موسى
آلاء عبد الزهرة كاظم
الفتلاوي، ظافرة جعفر عبد علي

Source

مجلة جامعة الكوفة لعلوم الحياة : مجلة علمية محكمة

Publisher

University of Kufa Faculty of Science Department of live Sciences

Publication Date

2016-12-31

Country of Publication

Iraq

No. of Pages

15

Main Subjects

Pharmacy, Health & Medical Sciences
Biology

Topics

• Woman
• Mutation
• Cancer
• Najaf
• Breast

English Abstract

100 samples of paraffin wax were excised from 50 women with tumors of breast glandular (Fibroadenoma )( FA) and 50 women with Ductal Carcinoma (DC) breast cancer, of some private laboratories and histopathological laboratory in Al-Sadr Medical City, were diagnosed Clinical stage and Histological grades of samples tumors breast ductal.

PCR technique was used in order to detect gene mutation in delAG 185 in exon 2 and insC 5382 in exon 20 in BRCA1 on chromosome 17, and del T 6174 Exon 11 in BRCA2 on chromosome 13 .

T-test revealed significant differences (p <0.001) between the ages , (44.47± 10.6 years; 25.38 ± 7.68years) of women with DC and FA respectively,.

PCR technique was indicated lack of BRCAs mutations in FA, so BRACs mutations showed high significance( p<0.0001) when compared DC (40%) to FA (0%).

Highly significanct frequency (p˂ 0.001) of mutations in BRCA1 14 ((28% ) compared to BRCA2 6 (% 12) in DC.

as well as significant difference (P <0.05) when compared frequency% of 185delAG 8 (16%) to 5382insC 6(12)%) in the BRCA1 and 6174 delT 6(12%) in BRCA2 BRCA2 mutations repeated more group aged (≥40 years) while BRCA1 be more frequent at the aged forty years upwards.

Data Type

Conference Papers

Record ID

BIM-750973

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