Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis
Joint Authors
Koryem, H. K.
al-Tawab, S. S.
Muftah, R. F.
al-Azzai, Umniyah E.
Tayel, M. Y.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 43, Issue 4 (31 Dec. 2016), pp.190-195, 6 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes.
Patients and methods The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria.
Those 40 patients were further divided into two groups.
Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6).
Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34).
All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, Creactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) andNCexamination.
In addition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves.
Results IL-17 level and NC changes showed a significant association in RA vasculitis patients.
Conclusion Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis
American Psychological Association (APA)
Koryem, H. K.& Tayel, M. Y.& al-Tawab, S. S.& Muftah, R. F.& al-Azzai, Umniyah E.. 2016. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation،Vol. 43, no. 4, pp.190-195.
https://search.emarefa.net/detail/BIM-753320
Modern Language Association (MLA)
Koryem, H. K.…[et al.]. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation Vol. 43, no. 4 (Oct. / Dec. 2016), pp.190-195.
https://search.emarefa.net/detail/BIM-753320
American Medical Association (AMA)
Koryem, H. K.& Tayel, M. Y.& al-Tawab, S. S.& Muftah, R. F.& al-Azzai, Umniyah E.. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation. 2016. Vol. 43, no. 4, pp.190-195.
https://search.emarefa.net/detail/BIM-753320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 195
Record ID
BIM-753320