Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis

Joint Authors

Koryem, H. K.
al-Tawab, S. S.
Muftah, R. F.
al-Azzai, Umniyah E.
Tayel, M. Y.

Source

Egyptian Rheumatology and Rehabilitation

Issue

Vol. 43, Issue 4 (31 Dec. 2016), pp.190-195, 6 p.

Publisher

The Egyptian Society for Rheumatology and Rehabilitation

Publication Date

2016-12-31

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Nutrition & Dietetics

Abstract EN

Objectives The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes.

Patients and methods The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria.

Those 40 patients were further divided into two groups.

Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6).

Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34).

All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, Creactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) andNCexamination.

In addition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves.

Results IL-17 level and NC changes showed a significant association in RA vasculitis patients.

Conclusion Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis

American Psychological Association (APA)

Koryem, H. K.& Tayel, M. Y.& al-Tawab, S. S.& Muftah, R. F.& al-Azzai, Umniyah E.. 2016. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation،Vol. 43, no. 4, pp.190-195.
https://search.emarefa.net/detail/BIM-753320

Modern Language Association (MLA)

Koryem, H. K.…[et al.]. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation Vol. 43, no. 4 (Oct. / Dec. 2016), pp.190-195.
https://search.emarefa.net/detail/BIM-753320

American Medical Association (AMA)

Koryem, H. K.& Tayel, M. Y.& al-Tawab, S. S.& Muftah, R. F.& al-Azzai, Umniyah E.. Study of the association between nail fold capillaroscopic changes and serum level of interleukin-17 in rheumatoid : a clue for emerging vaculitis. Egyptian Rheumatology and Rehabilitation. 2016. Vol. 43, no. 4, pp.190-195.
https://search.emarefa.net/detail/BIM-753320

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 195

Record ID

BIM-753320