تأثير الجرع دون السامة للسيلينيوم على الإجهاد التأكسدي في فروج اللحم

Abstract EN

This study was conducted to investigate the effect of subtoxic doses of selenium "Selenate" on the oxidative stress in broiler chickens by determining the level of Peroxynitrite radical ONOO- in serum and glutathione in liver and kidney tissue.Two hundred one day old broiler chicks type Rose have been used .

The birds were divided randomally into 4 groups.

The first group was fed the normal requirement 0.3mg/kg of diet.

The second group was fed 0.02 mg/kg of diet and this represented 30% of the median lethal dose LD50.The third one was fed 0.04 mg/kg of diet and this represented 60% of the median lethal dose LD50.The last group served as control.Results of this study indicated the presence of significant increase of ONOO- in the serum and also signifigant decrease in the level of glutathione in both liver and kidney tissues .The variation of these criteria was proportional synergestically with the amount fed and the length of exposure .The lowest figures were in the 3rd group fed 0.04 mg/ kg of diet, 24 days after oral administration.

From results of this study it was concluded that high doses of selenium for long period of time induce an increase in oxidative stress.