Vitamin D receptor gene variants in parkinson’s disease patients
Joint Authors
Meamar, Rokhsareh
Javadirad, Sayyid Murtada
Chitsaz, Niloofar
Ghahfarokhi, Mojgan Asadian
Kazimi, Mahdi
Ostadsharif, Maryam
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 3 (31 Jul. 2017), pp.225-230, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background: Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator.
Accumulating data provide evidences that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson’s disease (PD).
Aim: To find out whether the risk of the development of sporadic PD might be influenced by VDR gene polymorphisms in an Iranian population or not.
Subjects and methods: A genetic study was conducted to investigate the relationship between VDR gene polymorphisms and the severity of PD.
Fifty-nine PD patients and 53 matchedhealthy controls were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis.
For this purpose, four single nucleotide polymorphisms (SNPs) in VDR gene including FokI T > C (rs 10735810), BsmI A > G (rs 1544410), ApaI A >C (rs 7975232), and TaqI C> T (rs 731236) have been evaluated.
Results: Our genotyping studies revealed that holding ApaI a allele and FokI f allele could significantly increase the risk of developing Parkinson’s disease 1.85 and 2.46 times, respectively (p= 0.023 and 0.008).
Moreover, Aa heterozygous of ApaI also shows a significantly elevated risk of developing PD when compared to AA homozygous (OR = 7.44, p= 0.005).
For BsmI and TaqI polymorphisms, no significant difference in genotype or allele distribution was found between PD patients and the controls.
Moreover, in this study, no significant association was found between different genotypes and Hoehn & Yahr staging and Unified Parkinson Disease Rating Stage (UPDRS) rating scale.
American Psychological Association (APA)
Meamar, Rokhsareh& Javadirad, Sayyid Murtada& Chitsaz, Niloofar& Ghahfarokhi, Mojgan Asadian& Kazimi, Mahdi& Ostadsharif, Maryam. 2017. Vitamin D receptor gene variants in parkinson’s disease patients. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.225-230.
https://search.emarefa.net/detail/BIM-760007
Modern Language Association (MLA)
Meamar, Rokhsareh…[et al.]. Vitamin D receptor gene variants in parkinson’s disease patients. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.225-230.
https://search.emarefa.net/detail/BIM-760007
American Medical Association (AMA)
Meamar, Rokhsareh& Javadirad, Sayyid Murtada& Chitsaz, Niloofar& Ghahfarokhi, Mojgan Asadian& Kazimi, Mahdi& Ostadsharif, Maryam. Vitamin D receptor gene variants in parkinson’s disease patients. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.225-230.
https://search.emarefa.net/detail/BIM-760007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 229-230
Record ID
BIM-760007