Establishment of apoptotic regulatory network for genetic markers of colorectal cancer
Joint Authors
Hao, Yibin
Shan, Guoyong
Nan, Kejun
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.466-476, 11 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Topics
Abstract EN
Our purpose is to screen out genetic markers applicable to early diagnosis for colorectal cancer and to establish apoptotic regulatory network model for colorectal cancer, thereby providing theoretical evidence and targeted therapy for early diagnosis of colorectal cancer.
Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers applied to early diagnosis of colorectal cancer were searched to perform comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer.
Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to establish apoptotic regulatory network model based on screened genetic markers, and then verification experiment was conducted.
Through Meta analysis, seven genetic markers were screened out, including WWOX, K-ras, COX-2, p53, APC, DCC and PTEN, among which DCC shows highest diagnostic efficiency.
GO analysis of genetic markers found that six genetic markers played role in biological process, molecular function and cellular component.
It was indicated in apoptotic regulatory network built by KEGG analysis and verification experiment that WWOX could promote tumor cell apoptotic in colorectal cancer and elevate expression level of p53.
The apoptotic regulatory model of colorectal cancer established in this study provides clinically theoretical evidence and targeted therapy for early diagnosis of colorectal cancer.
American Psychological Association (APA)
Hao, Yibin& Shan, Guoyong& Nan, Kejun. 2017. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.466-476.
https://search.emarefa.net/detail/BIM-761730
Modern Language Association (MLA)
Hao, Yibin…[et al.]. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.466-476.
https://search.emarefa.net/detail/BIM-761730
American Medical Association (AMA)
Hao, Yibin& Shan, Guoyong& Nan, Kejun. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.466-476.
https://search.emarefa.net/detail/BIM-761730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 475-476
Record ID
BIM-761730