Angiotensin II-accelerated vulnerability of carotid plaque in a cholesterol-fed rabbit model-assessed with magnetic resonance imaging comparing to histopathology
Joint Authors
Li, Xiao
Sun, Beibei
Zhao, Huilin
Yao, Hong
Liu, Xiaosheng
Lu, Qing
Wan, Jieqing
Xu, Jianrong
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.495-503, 9 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
This study sought to reveal the effect of angiotensin II (Ang II)-induced atherosclerotic vulnerability in rabbits and to determine whether in vivo magnetic resonance imaging (MRI) can determine the effect of Ang II on atherosclerotic development over time.
In total, 24 elderly male New Zealand white rabbits underwent an intravascular balloon injury in the left common carotid artery (LCCA) and were subsequently fed a high cholesterol diet for 12 weeks.
At 8 weeks, rabbits were randomly assigned to receive either Ang II (1.4 mg/kg/d, Ang II group) or vehicle (phosphatebuffered saline, control) via a subcutaneous osmotic minipump for 4 weeks.
The rabbits were imaged three times: at baseline and at 8 and 12 weeks.
After the 12-week MRI scanning, rabbits were euthanized to obtain pathological and histological data.
Atherosclerotic plaques were identified in the 21 rabbits that survived the 12-week trial.
Typical feature of vulnerable plaques (VP), intraplaque hemorrhage, were observed in 6 of 10 animals (60.0%) in the Ang II group.
The Cohen K value of MR imaging between the AHA classifications was 0.82 (0.73–0.91; P < 0.001).
MRI revealed that the change in carotid morphology were significantly different between the Ang II and control group plaques.
Our results support an important role for Ang II in plaque vulnerability by promoting intraplaque neovascularization and hemorrhage as well as inflammation.
The vulnerable features induced by Ang II in rabbit carotid plaques could be accurately monitored with MRI in vivo and confirmed with histomorphology.
American Psychological Association (APA)
Sun, Beibei& Zhao, Huilin& Li, Xiao& Yao, Hong& Liu, Xiaosheng& Lu, Qing…[et al.]. 2017. Angiotensin II-accelerated vulnerability of carotid plaque in a cholesterol-fed rabbit model-assessed with magnetic resonance imaging comparing to histopathology. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.495-503.
https://search.emarefa.net/detail/BIM-761750
Modern Language Association (MLA)
Sun, Beibei…[et al.]. Angiotensin II-accelerated vulnerability of carotid plaque in a cholesterol-fed rabbit model-assessed with magnetic resonance imaging comparing to histopathology. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.495-503.
https://search.emarefa.net/detail/BIM-761750
American Medical Association (AMA)
Sun, Beibei& Zhao, Huilin& Li, Xiao& Yao, Hong& Liu, Xiaosheng& Lu, Qing…[et al.]. Angiotensin II-accelerated vulnerability of carotid plaque in a cholesterol-fed rabbit model-assessed with magnetic resonance imaging comparing to histopathology. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.495-503.
https://search.emarefa.net/detail/BIM-761750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 502-503
Record ID
BIM-761750