The relationship between serum homocysteine and highly sensitive creactive protein levels in children on regular hemodialysis
Joint Authors
Ibrahim, Suhayr
Pessar, Shayma Abd al-Malik
al-Mursi, Iman
Abd al-Salam, Manal
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 3 (30 Jun. 2017), pp.483-490, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-06-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Hyperhomocysteinemia has attracted a lot of attention in renal patients, not only because of its close relationship with renal function but also because it has been implicated as an independent cardiovascular risk factor in these patients.
An increased level of C-reactive protein (CRP) has been reported to be a strong predictor of cardiovascular mortality in hemodialysis (HD) patients.
The aim of this study was to assess the association between homocysteine (Hcy) and highly sensitive CRP (hsCRP) in cardiovascular risk prediction in children with chronic kidney disease (CKD) on HD.
This case–control study was conducted on 40 children with CKD on regular HD and 20 age- and sex-matched healthy children as controls.
Their ages ranged from 4 to 18 years, and they were selected from the pediatric nephrology and HD unit at Al-Azhar University Hospital, during the period from May 2015 to April 2016.
Complete blood count, serum ferritin, cholesterol, triglycerides, calcium, phosphorus, parathormone (PTH), Hcy, and hsCRP levels were measured in both groups.
Measurements of anthropometry and blood pressure (BP) were performed.
There was a significant increase in serum Hcy levels in cases than controls; it was 17.22 ± 9.66 μmol/L and 6.32 ± 1.47 μmol/L, respectively (P <0.01).
Furthermore, there was a significant increase in hsCRP in patients than controls; 2.73 ± 2.65 and 0.9 ± 0.85, respectively (P <0.01).
There was a significant positive correlation between hsCRP and Hcy with BP, cholesterol, triglyceride, PTH, and ferritin levels.
Our data highlighted the important correlation between serum Hcy and hsCRP to detect high-risk patients for subsequent cardiovascular disease and utility of preventive strategies that attenuate inflammatory risk.
American Psychological Association (APA)
Abd al-Salam, Manal& Ibrahim, Suhayr& Pessar, Shayma Abd al-Malik& al-Mursi, Iman. 2017. The relationship between serum homocysteine and highly sensitive creactive protein levels in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 3, pp.483-490.
https://search.emarefa.net/detail/BIM-767408
Modern Language Association (MLA)
Abd al-Salam, Manal…[et al.]. The relationship between serum homocysteine and highly sensitive creactive protein levels in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 3 (May. / Jun. 2017), pp.483-490.
https://search.emarefa.net/detail/BIM-767408
American Medical Association (AMA)
Abd al-Salam, Manal& Ibrahim, Suhayr& Pessar, Shayma Abd al-Malik& al-Mursi, Iman. The relationship between serum homocysteine and highly sensitive creactive protein levels in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 3, pp.483-490.
https://search.emarefa.net/detail/BIM-767408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 498-490
Record ID
BIM-767408