Outcome of recipients of human leukocyte antigen incompatible kidney transplants who underwent desensitization at King Fahad Specialist Hospital, Dammam, Saudi Arabia
Joint Authors
Idris, Muhammad Abd al-Rahim
Husayn, Akhtar
Muntasir, Muhammad Abd al-Rahman
Marmi, Adnan
al-Dajani, Ahmad Abd al-Fattah
al-Jaman, Yusuf Muhammad
Akhtar, Mahmud
Husawi, Abd al-Rahman
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 3 (30 Jun. 2017), pp.449-506, 58 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-06-30
Country of Publication
Saudi Arabia
No. of Pages
58
Main Subjects
Topics
Abstract EN
In patients whom are highly sensitized immunologically, the benefit of kidney transplantation can be extended to this population through the utilization of organs from human leukocyte antigen incompatible (HLAi) donors.
This retrospective observational study was designed to identify the incidence and predictors of acute antibody-mediated rejection/acute cellular rejection (AMR/ACR) in our kidney recipients from living kidney donors (sensitized and those with low immunologic risk).
This single-center study has been conducted at King Fahad Specialist Hospital, Dammam (KFSH-D), Saudi Arabia; during the period of September 2008– August 2013.
All eligible recipients of living donor kidneys during the study period were included (n = 213) in the study.
Over 60% of patients in the study were females.
Thirty of the 213 kidneys were from HLAi donors.
During the follow-up period (median follow-up time = 16 months; 3–27 months), the incidence rate of ACR among HLA compatible (HLAc) and HLAi groups was 22.2% and 16.7%, respectively (P >0.05).
The incidence rate of AMR was 2.6% in HLAc group and 16.7%in the HLAi group (P <0.05).
The significantly higher incidence of AMR in HLAi group can be explained by the presence of the donor-specific antibodies in weak titers.
These results are consistent with studies from similar populations in published literature.
However, the relatively small number and short duration of the study are considered, and longer follow-up of this population will be needed for conclusions on the sustainability of our findings.
American Psychological Association (APA)
Idris, Muhammad Abd al-Rahim& Husayn, Akhtar& Muntasir, Muhammad Abd al-Rahman& Marmi, Adnan& al-Dajani, Ahmad Abd al-Fattah& al-Jaman, Yusuf Muhammad…[et al.]. 2017. Outcome of recipients of human leukocyte antigen incompatible kidney transplants who underwent desensitization at King Fahad Specialist Hospital, Dammam, Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 3, pp.449-506.
https://search.emarefa.net/detail/BIM-767413
Modern Language Association (MLA)
Idris, Muhammad Abd al-Rahim…[et al.]. Outcome of recipients of human leukocyte antigen incompatible kidney transplants who underwent desensitization at King Fahad Specialist Hospital, Dammam, Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 3 (May. / Jun. 2017), pp.449-506.
https://search.emarefa.net/detail/BIM-767413
American Medical Association (AMA)
Idris, Muhammad Abd al-Rahim& Husayn, Akhtar& Muntasir, Muhammad Abd al-Rahman& Marmi, Adnan& al-Dajani, Ahmad Abd al-Fattah& al-Jaman, Yusuf Muhammad…[et al.]. Outcome of recipients of human leukocyte antigen incompatible kidney transplants who underwent desensitization at King Fahad Specialist Hospital, Dammam, Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 3, pp.449-506.
https://search.emarefa.net/detail/BIM-767413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 505-506
Record ID
BIM-767413