مستويات الترومبوموديولين البلازمية لدى أطفال سوريين مصابين بابيضاض الدم اللمفاوي الحاد

Abstract EN

Acute lymphoblastic leukemia is one of the most common childhood malignancies, representing nearly one-third of all pediatric cancers with a peak incidencein children aged 2-5 years.

Thrombomodulin is cell surface-expressed membrane glycoprotein which is originally identified on vascular endothelium.

Its plasma level depends on the integrity of the endothelium, and have been used as indexes of endothelial dysfunction.

The aim of this study was to assess plasma thrombomodulin levels in Syrian children with acute lymphoblastic leukemia(ALL), during acute phase of the disease to assess their potential prognostic value.

The study has been done at Children University Hospital in Damascus between 2016-2017.

This study included 30 children diagnosed with acute lymphoblastic leukemia (ALL) before starting with a chemotherapy.

The levels of thrombomodulin were measured by Enzyme Linked Immuno Sorbent Assay (ELISA).

In a result, there was a significant increase in soluble thrombomodulin levels during the acute phase of the disease in children with an unfavorable, prognosis comparison with children with favorable prognosis.

So, plasma thrombomodulin levels might represent an additional prognostic marker in childhood acute lymphoblastic leukemia