دور البروتين الرابط لعامل النمو الشبيه بالأنسولين 2 في مناظرة علاج أطفال سوريين مصابين بابيضاض دم لمفاوي حاد

Abstract EN

Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) have been reported to play an important role in tumor proliferation and treatment resistant.

This study aimed to investigate the validity of measuring IGFBP-2 in the serum of Syrian children with acute lymphoblastic leukemia (ALL) as additional marker in diagnosis and follow-up of the disease.

IGFBP-2 was determined in the sera of 33 ALL patients at time of diagnosis and after an intensification phase of chemotherapy (IPC) that lasts about 6 months, as well as in 21 healthy children as a control group, using enzyme-linked immunosorbent assay (ELISA) technique.

At time of diagnosis, serum IGFBP-2 was significantly higher than those in the control group at diagnosis, but returned to normal value after IPC.

In conclusion, the changes in IGF system could be useful to support diagnosis and follow-up of children with ALL