Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients : a hospital-based cross-sectional study
Joint Authors
Etta, Praveen Kumar
Gupta, Amit
Sharma, R. K.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 4 (31 Aug. 2017), pp.874-885, 12 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-08-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Nutrition & Dietetics
Medicine
Topics
Abstract EN
We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India.
This is cross-sectional observational study.
A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)].
Symptoms related to CKD-mineral bone disorder were seen in 33.6% of the study patients.
Prevalence of hypocalcemia, hyperphosphatemia, hyperparathyroidism, and hypovitaminosis D was 64.2%, 81.1%, 49.5%, and 89.5%, respectively.
CVC was seen in 22.1% of patients on echocardiography, mostly involving the mitral valve.
Patients with CVC were more likely to be males and smokers.
There was no significant difference in iPTH levels between patients with or without CVC.
AAC was seen in 10.5% of patients on lateral abdominal X-ray.
Patients with AAC had higher levels of iPTH, phosphorus, and ALP and lower levels of calcium compared to patients without AAC.
BMD by DXA showed a low bone mass in 41.05% of our patients and was more prevalent in CKD stage 5.
Most of the study patients had hyperparathyroidism and low 25(OH)D levels.
Our study shows that newly detected, naïve Indian CKD patients have a high prevalence of disturbances of mineral metabolism including
American Psychological Association (APA)
Etta, Praveen Kumar& Sharma, R. K.& Gupta, Amit. 2017. Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients : a hospital-based cross-sectional study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 4, pp.874-885.
https://search.emarefa.net/detail/BIM-776153
Modern Language Association (MLA)
Etta, Praveen Kumar…[et al.]. Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients : a hospital-based cross-sectional study. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 4 (Jul. / Aug. 2017), pp.874-885.
https://search.emarefa.net/detail/BIM-776153
American Medical Association (AMA)
Etta, Praveen Kumar& Sharma, R. K.& Gupta, Amit. Study of chronic kidney disease-mineral bone disorders in newly detected advanced renal failure patients : a hospital-based cross-sectional study. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 4, pp.874-885.
https://search.emarefa.net/detail/BIM-776153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 884-885
Record ID
BIM-776153