Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population : a case-control study
Joint Authors
Nissar, Saniya
Samir, Agah Sayyid
Rasul, Ruhi
Qadri, Qurtibah
Chowdri, Nissar A.
Rashid, Fawziyah
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 1 (31 Jan. 2017), pp.53-59, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Colorectal carcinogenesis has been found to be associated with the polymorphic status of Toll-like receptor 4 gene in various populations of the world.
Aim : The aim of the study was to determine the genetic association of TLR4 gene polymorphisms (Asp299Gly and Thr399Ile) with disease susceptibility and risk development in colorectal cancer (CRC) patients of Kashmir, India.
Materials and methods : Genotype frequencies of TLR4 polymorphisms (Asp299Gly and Thr399Ile) were compared between 120 CRC patients and 200 healthy controls using PCRRFLP method.
Results : We did not find any significant association between the TLR4 gene polymorphisms and the CRC cases (p>0.05).
However CT genotype (Thr399Ile) showed modest elevated risk of the development of CRC [OR = 1.78 95% CI (0.88–3.5)].
Also G allele (AG genotype) of TLR-4 Asp299Gly polymorphism was found to be significantly associated with the male gender (p value = 0.006) and involvement of Nodes (p value = 0.01) whereas, T allele (CT genotype) of Thr399Ile polymorphism showed significant association with the smoking status (p value = 0.03).
Conclusion : Our results suggest that TLR4 gene polymorphism is not a key modulator of the risk of developing colorectal cancer in Kashmiri population
American Psychological Association (APA)
Nissar, Saniya& Samir, Agah Sayyid& Rasul, Ruhi& Qadri, Qurtibah& Chowdri, Nissar A.& Rashid, Fawziyah. 2017. Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population : a case-control study. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 1, pp.53-59.
https://search.emarefa.net/detail/BIM-777817
Modern Language Association (MLA)
Nissar, Saniya…[et al.]. Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population : a case-control study. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 1 (Jan. 2017), pp.53-59.
https://search.emarefa.net/detail/BIM-777817
American Medical Association (AMA)
Nissar, Saniya& Samir, Agah Sayyid& Rasul, Ruhi& Qadri, Qurtibah& Chowdri, Nissar A.& Rashid, Fawziyah. Role of TLR4 gene polymorphisms in the colorectal cancer risk modulation in ethnic Kashmiri population : a case-control study. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 1, pp.53-59.
https://search.emarefa.net/detail/BIM-777817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 57-59
Record ID
BIM-777817