Rock signaling control PPARγ expression and actin polymerization during adipogenesis
Joint Authors
Zhao, Jing
Ji, Yuntao
Cao, Meixia
Chen, Yanfei
Li, Xiaoli
Qu, Changqing
Liu, Jia
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1866-1870, 5 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Aim : Adipogenesis is characterized by a strong interdependence between cell shape, cytoskeletal organization, and the onset of adipogenic gene expression.
Here we investigated the role of the RhoA/ROCK pathway in adipogenesis.
Result : high RhoA activity in the cell line C3H10T1/2 were generated (Named RhoA14V cells).
Treatment of RhoA14V cells with Shield 1 following their differentiation into adipocytes resulted in the appearance of thick cortical actin filaments, and increased mRNA expression levels of RhoA, ROCK, p-MYPT1 and p-MLC, while PPARc mRNA decreased.
This resulted in decreased triglyceride synthesis and reduced expression of the adipogenic transcription factor PPARc.
These molecular changes were accompanied by reorganization of the actin cytoskeleton, during which ROCK signaling suppressed actin polymerization.
Conclusion: ROCK signaling suppresses adipogenesis by controlling PPARc expression and actin organization in adipocytes.
American Psychological Association (APA)
Ji, Yuntao& Cao, Meixia& Liu, Jia& Chen, Yanfei& Li, Xiaoli& Zhao, Jing…[et al.]. 2017. Rock signaling control PPARγ expression and actin polymerization during adipogenesis. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1866-1870.
https://search.emarefa.net/detail/BIM-780614
Modern Language Association (MLA)
Ji, Yuntao…[et al.]. Rock signaling control PPARγ expression and actin polymerization during adipogenesis. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1866-1870.
https://search.emarefa.net/detail/BIM-780614
American Medical Association (AMA)
Ji, Yuntao& Cao, Meixia& Liu, Jia& Chen, Yanfei& Li, Xiaoli& Zhao, Jing…[et al.]. Rock signaling control PPARγ expression and actin polymerization during adipogenesis. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1866-1870.
https://search.emarefa.net/detail/BIM-780614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1869-1870
Record ID
BIM-780614