Indigofera oblongifolia leaf extract regulates spleen macrophage response during Plasmodium chabaudi infection
Joint Authors
Lubbad, Mahmud Y.
Tayyib, Nuri T.
al-Shuaybi, Isam M.
Dakhil, Muhammad A.
Mubaraki, Murad A.
Hafiz, Taghrid A.
Luqman, Maha S.
al-Ghamidi, Ali O.
Bayyumi, al-Sayyid M.
al-Qurayshi, Salih
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 7 (30 Nov. 2017), pp.1663-1666, 4 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Malaria is a major health problem that still affects numerous countries.
The current study aimed to identify the role of Indigofera oblongifolia leaf extract in regulating mouse spleen macrophages during the progression of Plasmodium chabaudi infection.
Three doses of the leaf extract (100, 200, and 300 mg/kg) were administered to mice inoculated with P.
chabaudi infected erythrocytes.
The weight of the infected mice improved after the treatment with I.
oblongifolia.
The infection causes disorganization of macrophage distribution in the spleen.
After the mice had been treated with the leaf extract, the macrophages appeared to be reorganized in the white and red pulp areas.
In addition, the I.
oblongifolia leaf extract (IOLE) significantly increased the total antioxidant capacity of the mice spleens infected with P.
chabaudi.
The phagocytic activity of spleen macrophages was increased in the infected group as indicated by the significant decrease in the number of fluorescent particles in the spleen sections.
This number increased in the mice spleens after treatment with IOLE.
Based on these results, it is suggested that IOLE regulate macrophage response of the spleen during the blood stage of malaria in mice.
American Psychological Association (APA)
al-Shuaybi, Isam M.& Tayyib, Nuri T.& Mubaraki, Murad A.& Hafiz, Taghrid A.& Luqman, Maha S.& al-Ghamidi, Ali O.…[et al.]. 2017. Indigofera oblongifolia leaf extract regulates spleen macrophage response during Plasmodium chabaudi infection. Saudi Journal of Biological Sciences،Vol. 24, no. 7, pp.1663-1666.
https://search.emarefa.net/detail/BIM-781819
Modern Language Association (MLA)
al-Shuaybi, Isam M.…[et al.]. Indigofera oblongifolia leaf extract regulates spleen macrophage response during Plasmodium chabaudi infection. Saudi Journal of Biological Sciences Vol. 24, no. 7 (Nov. 2017), pp.1663-1666.
https://search.emarefa.net/detail/BIM-781819
American Medical Association (AMA)
al-Shuaybi, Isam M.& Tayyib, Nuri T.& Mubaraki, Murad A.& Hafiz, Taghrid A.& Luqman, Maha S.& al-Ghamidi, Ali O.…[et al.]. Indigofera oblongifolia leaf extract regulates spleen macrophage response during Plasmodium chabaudi infection. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 7, pp.1663-1666.
https://search.emarefa.net/detail/BIM-781819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1666
Record ID
BIM-781819