Alport’s syndrome with focal segmental glomerulosclerosis lesion-pattern to recognize
Joint Authors
al-Sad, Khalid O.
al-Sahli, Afnan A.
al-Shahwan, Sarah I.
al-Utaybi, Amal O.
al-Udah, Nurah
Faruqi, Mahfuz
al-Sayyari, Abd Allah A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 1 (28 Feb. 2018), pp.167-172, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The association between Alport’s syndrome (AS) and focal segmental glomerulosclerosis (FSGS) in the same patient is complex and rarely reported.
We report a case of a 42- year-old male presenting with proteinuria, microscopic hematuria, elevated serum creatinine and hypertension with unremarkable physical examination apart from obesity.
The renal biopsy showed well-established FSGS pattern of injury with mild interstitial fibrosis and tubular atrophy, while the electron microscopic examination demonstrated glomerular basement membranes (GBM) changes compatible with AS.
AS can be complicated by segmental glomerular scarring, which can mimic primary FSGS, while familial FSGS can result from mutations in collagen IV network of the GBM.
This overlap can complicate histopathological interpretation of renal biopsy, which should be accompanied by mutational analysis for accurate diagnosis and proper therapeutic intervention.
American Psychological Association (APA)
al-Sahli, Afnan A.& al-Shahwan, Sarah I.& al-Utaybi, Amal O.& al-Sad, Khalid O.& al-Udah, Nurah& Faruqi, Mahfuz…[et al.]. 2018. Alport’s syndrome with focal segmental glomerulosclerosis lesion-pattern to recognize. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 1, pp.167-172.
https://search.emarefa.net/detail/BIM-781986
Modern Language Association (MLA)
al-Sahli, Afnan A.…[et al.]. Alport’s syndrome with focal segmental glomerulosclerosis lesion-pattern to recognize. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 1 (Jan. / Feb. 2018), pp.167-172.
https://search.emarefa.net/detail/BIM-781986
American Medical Association (AMA)
al-Sahli, Afnan A.& al-Shahwan, Sarah I.& al-Utaybi, Amal O.& al-Sad, Khalid O.& al-Udah, Nurah& Faruqi, Mahfuz…[et al.]. Alport’s syndrome with focal segmental glomerulosclerosis lesion-pattern to recognize. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 1, pp.167-172.
https://search.emarefa.net/detail/BIM-781986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 172
Record ID
BIM-781986