تحضير و تقيم أغشية بوليمرية رقيقة من الكيتوسان محملة بدواء الكلورامفينيكول كضمادات للجروح

Abstract EN

The purpose of this research work was to prepare, develop and evaluate controlled release transdermal delivery of chloramphenicol with hydrophilic polymers including:chitosan by solvent casting technique.We has used chloramphenicol injection which was available in the commercial pharmacies chloramphenicol was separated and was purified by using two solvents.

To investigate from the purity of chloramphenicol , the melting point and λ max were determined for the purpose of ascertaining the purity of the material used, and then was prepared gels chitosan and in the form of a number of thin polymeric film loaded with drug chloramphenicol and different concentrations ((0.1, 0.2, 0.3g), as well as other models change polymer ratios (1,2,3 g) The sampls were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC).In vitro release profiles were studied in pH=7.4,the result showed the release rates which were reduced upon increasing the amount polymer.

The coefficient of determination indicated that the release data was best fitted with zero order kinetics.

Higuchi The purpose of this research work was to prepare, develop and evaluate controlled release transdermal delivery of chloramphenicol with hydrophilic polymers including:chitosan by solvent casting technique.We has used chloramphenicol injection which was available in the commercial pharmacies chloramphenicol was separated and was purified by using two solvents.

To investigate from the purity of chloramphenicol , the melting point and λ max were determined for the purpose of ascertaining the purity of the material used, and then was prepared gels chitosan and in the form of a number of thin polymeric film loaded with drug chloramphenicol and different concentrations ((0.1, 0.2, 0.3g), as well as other models change polymer ratios (1,2,3 g) The sampls were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC).In vitro release profiles were studied in pH=7.4,the result showed the release rates which were reduced upon increasing the amount polymer.

The coefficient of determination indicated that the release data was best fitted with zero order kinetics.

Higuchi equation explains the diffusion controlled release mechanism.

equation explains the diffusion controlled release mechanism.