Cytotoxic T-lymphocyte associated antigen-4 (+49A G) gene polymorphism as a protective factor against toxoplasmosis
Other Title(s)
التغاير الوراثي حادي النيوكليوتيد (+49A G) في جين مستضد-4 المقترن مع الخلايا اللمفاوية التائية السامة كعامل حماية ضد الإصابة بداء المقوسات
Author
Source
Issue
Vol. 14, Issue 2 (30 Jun. 2017), pp.240-246, 7 p.
Publisher
University of Babylon College of Medicine
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Cytotoxic T-Lymphocyte Associated Antigen-4 (CTLA-4) is a key factor in immune regulation.
Polymorphisms in CTLA-4 gene may influence the status of this factor and eventually the immune response of host against the infectious agents.
This response becomes of particular importance in cases when the pathogen is an opportunistic such as Toxoplasma gondii.
This study aimed to explore the effect of CTLA-4+49A/G single nucleotide polymorphism (SNP) on the susceptibility to toxoplasmosis in women.
Genomic DNA was isolated from 59 women with toxoplasmosis and aged matched 60 Toxoplasma-free women as controls.
Tetra-Primer Amplification Refractory System-Polymerase Chain Reaction (ARMS-PCR) was used for amplification and genotyping of CTLA-4 gene using specific primers.
The heterozygous genotype (AG) and G allele of the polymorphism CTLA-4+49A/G were less frequent among cases (17.12% and 16.95% respectively) than controls (40% and 35% respectively) with significant differences (OR=0.379, 95%CI=0.206-0.697, P=0.002).
These data strongly suggested the protective role of CTLA-4+49G against toxoplasmosis among Iraqi women.
American Psychological Association (APA)
Allami, Risalah Husayn. 2017. Cytotoxic T-lymphocyte associated antigen-4 (+49A G) gene polymorphism as a protective factor against toxoplasmosis. Medical Journal of Babylon،Vol. 14, no. 2, pp.240-246.
https://search.emarefa.net/detail/BIM-795410
Modern Language Association (MLA)
Allami, Risalah Husayn. Cytotoxic T-lymphocyte associated antigen-4 (+49A G) gene polymorphism as a protective factor against toxoplasmosis. Medical Journal of Babylon Vol. 14, no. 2 (2017), pp.240-246.
https://search.emarefa.net/detail/BIM-795410
American Medical Association (AMA)
Allami, Risalah Husayn. Cytotoxic T-lymphocyte associated antigen-4 (+49A G) gene polymorphism as a protective factor against toxoplasmosis. Medical Journal of Babylon. 2017. Vol. 14, no. 2, pp.240-246.
https://search.emarefa.net/detail/BIM-795410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 245-246
Record ID
BIM-795410