تقييم الفعالية العلاجية لمستخلصات الطحلب الأخضر Enteromorpha intestinalis (L.)‎ Nees (1820)‎ ضد الأكياس العدرية للمشوكة الحبيبية Echinococcus granulosus داخل الجسم الحي باستخدام الفئران المختبرية Balb \ c

Abstract EN

The present study was conducted during the period between January 2014 until December 2015 in order to evaluate the inhibitory activity of green algae E.intestinalis extracts compared with drug albendazole against the larval stage of the E.

granulosus.

The hydatid cysts are collected from livers and lungs of infected naturally sheep , The alga samples were collected from the marshland in Abu Sakhir area north of Basra, The results of the current study has shown that the average number of hydatid cysts in the livers of infected laboratory mice is the least with a drug albendazole treatment, While the treatment with 698 mg / ml methanol extract was the best among all other algal extracts treatments to influence on the member of the hydatid cysts in infected organs followed by treatment with 804 mg / ml of hexane extract.

The results showed that treatment with 698 mg / ml of methanol extract was significantly the best among all other treatments in reducing the infected organs weights compared to the positive control group.

The study found that liver ALT , AST enzymes values was significantly high in the serum of the positive control group compared with the negative control group and the all other groups, also the study found that the value of the enzyme ALT for the group treated with Albendazole was the approach for its value in a negative control, Also found a significant decrease in liver enzymes ALT and AST values of the groups treated with methanol extract compared with the values of these enzymes in the positive control group and that the decline was not significant with a negative control group.

In the histological study the liver of positive control group has suffered from congestion and degeneration of some of its cells as well as the little infiltration of inflammatory cells, the spleen has swelled, the lungs appeared hyperplasia in some epithelial tissue areas how lining the vesicles lead to narrow of these vesicles, also appeared infiltration of the inflammatory cells in the some areas of lung tissue, while the bleeding was observed in kidney tissue in some areas as well as the infiltration of inflammatory cells in other parts of it.