The cytoprotective effect of crocin on oxaliplatin treated vero cell line

Abstract EN

Cancer is a disease characterized by a shifted in the control mechanism that governs cell survival, proliferation and differentiation.

There are many types of treatment to the cancer like surgery, radiation, chemotherapy, immunotherapy and others.

Each of these above treatments has its indication effect and has Sid effect and / or adverse effect.

The chemotherapy is one type of this treatment to the cancer that have the indication effect, side effect and adverse effect.

There are many type of chemotherapeutic agent that used for this type of cancer one of them it is platinum compound (cisplatin, oxaliplatin and others).

There are two types of limitation in the use of these agents one of them is the side effect which is neurotoxicity, Ototoxicity, nephrotoxicity, and etc.

and the second one is the resistance of cancer cells to these agents.