تقييم الدور الوقائي لحليب الأفراس المخمر في التخفيف من أثار الإجهاد التأكسدي المستحدث بخلات الرصاص في الجرذان البيضاء

Abstract EN

This study was carried out at college of veterinary medicine /AL-Qadisiya university during the period from 27-2-2014 to 30-3-2014 to evaluate the role of fermented mares milk in alleviate the effect of oxidative stress induced by lead acetate.

A total of (40) male albino rats were used in this study, the rats were divided randomly into four groups including (10 rats per each group) as following: Control group (C) fed only standard diet and water for drinking, first treatment group (T1) fed the same diet and deionized distilled water intoxicated with (1000 ppm) lead acetate, second treatment group (T2) fed the same diet and deionized distilled water intoxicated with (1000ppm) lead acetate, and orally received fermented mares milk (10 ml /kg B.W) by gavage, third treatment group (T3) fed the same diet and deionized distilled water intoxicated with (1000 ppm) lead acetate and orally received (50 mg / kg B.W) Ca-EDTA by gavage.

The results showed that intoxicated with lead acetate causes a significant (P<0.05) increase in activity of (AST, ALT and ALP) enzymes.

Also the result revealed that a significant (P<0.05) decrease in activity of super dismutase (SOD) enzyme and a significant (P<0.05) increase in concentration of serum malondialdehyd (MDA) in the blood serum group.

On the other hand the result showed that giving fermented mares milk or EDTA with lead acetate contribute in improvement of previous parameters as compared to (T1) and closely to control group.

According to the results obtained in the present study, it could be concluded that exposed to lead acetate can be causes disturbance in physiological functions and induced oxidative stress besides approved the protective role of fermented mares milk in liver protection.