التأثيرات الكيموحيوية و النسجية لخلات اليورانيل المائية في ذكور الأرانب النيوزلندية

Abstract EN

The study aimed to demonstrate the effects of two doses (30 and 40 mgkg) of aqueous uranium acetate on the blood biochemical criteria and histological changes in male New Zealand rabbits.

Eighteen (18) rabbits divided into three equal groups (control, T1, T2) were daily gavaged for 21 days.

Control group: given 1 ml kg BW of normal saline 0.9%.

The first and the second treated groups were treated with 30 mg kg, and 40 mgkg BW of the aqueous uranium acetate respectively.

Results show presence of a significant increase (P<0.05) in the blood level of urea, creatinine, triglycerides (TG), cholesterol, GOT and blood glucose of both treated groups in compare with control, also show a significant decrease in blood total protein of both treated groups compare with control.

Histologically the kidney of treated animals showed existence conglomerate and a contraction in the glomerulus and shedding of the endothelium of Bowman's capsule, congestion and expansion of the urinary tubules, cellular death, and damage to the installation of the total tissue.

In the liver there were marked damage of the radiated installation of liver, liver cellular death, congestion and endothelium shedding of the central vein, and presence of RBCs in the dilated sinusoids.

In conclusion, taking of uranyl acetate in high concentrations lead to histopathological changes in body tissue, and to significant changes in blood biochemical criteria with serious effects on the body.