أقراص الديكسكلور فينارامين ماليات الطافية : صياغتها و تقييمها باستخدام التصميم العاملي

Abstract EN

The purpose of this research was to formulate and evaluation a floating tablet formulation of Dexchlorphenaramine maleate (DCPM) using full factorial design.

DCPM has an absorption window in the stomach and in the upper part of the small intestine .A 32 factorial design (nine runs) was utilized to optimize the formulation wherein the content of hydroxypropyl methyl cellulose (HPMC K15M) (X1) and Carbopol 934P (X2) were taken as independent variables and t50% (Y1), drug release after 6 h (Y2), % drug release after 12 h (Y3), and floating lag time (FLT) (Y4) were taken as the dependent variables.

We used HPMC K15M and Carbopol 934P as matrix materials for formulating the tablets, which were prepared by direct compression.

The floating tablets were evaluated for uniformity of weight, hardness, friability, tablet assay, in vitro floating and in vitro release studies.

Floating matrix tablets based on combination of two polymers exhibited desired floating and prolonged drug release for 24 h.

Carbopol loading showed negative effect on floating properties but were found helpful to control the release rate of drug.

Optimal Formula (F9) was selected by regression analysis which followed Krosmayer-peppas kinetic.

Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion.

The developed floating tablets of DCPM may be used in clinic for prolonged drug release for at least 16 hrs, thereby improving the bioavailability of the drug and patient compliance.