تأثير الدايفنهايدرامين في التغيرات المحدثة بالاميدوكارب في نشاط خميرة الكولين استراز و حركة الأمعاء الدقيقة في أفراخ الدجاج

Other Title(s)

Effect of diphenhydramine on the changes in cholinesterase activity and intestinal motility induced by imidocarb in chicks

Joint Authors

ندى خليل إبراهيم
غادة عبد المنعم فارس

Source

المجلة العراقية للعلوم البيطرية

Publisher

University of Mosul College of Veterinary Medicine

Publication Date

2012-12-31

Country of Publication

Iraq

No. of Pages

7

Main Subjects

Zoology
Veterinary Medicine

Topics

• Small intestine
• Chickens
• Yeasts
• Cholinesterases

English Abstract

This study examines and evaluates the interaction between imidocarb and diphenhydramine on the level of cholinesterase activity and small intestinal transit (SIT) in chicks.

Imidocarb at 45 mg/kg,s.c.

significantly inhibited plasma and brain cholinesterases, 30 min after injection by 69 and 21%, respectively.

Diphenhydramine at 5 mg/kg, s.c significantly inhibited plasma and brain cholinesterase by 29.7 and 35.7%, respectively and significantly decreased the inhibitory effect of imidocarb on plasma cholinesterase by 33.2%.

Imidocarb at 40 mg/kg, s.c.

significantly increased SIT 15 and 30 min after injection by 92, 100%, respectively.

Diphenhydramine at 5 and 10 mg/kg, s.c., 15 min before imedocarb at 40mg/kg, s.c.

significantly decreased SIT produced by imidocarb alone by 80.6 and 70.5 %, respectively and prevented the SIT when given immediately after imedocarb at 40 mg/kg, s.c.

by 100%.The data revealed that diphenhydramine has a beneficial effect in controlling the SIT modulated by imidocarb in chicks and there was no adverse interaction between two drugs at the level of cholinesterase.

Data Type

Conference Papers

Record ID

BIM-830721

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